Episode 53: How Gene Therapy Might Change Our Lives—The Top Resource to Extend Human Lifespan Forever with Dr. Ryan Rossner, Director of Longevity Research at MiniCircle
Episode Highlights:
In this episode of the BiohackerBlondie Podcast, Jenny Jones sits down with Dr. Ryan Rossner, Director of Longevity Research at MiniCircle, to discuss how gene therapy is shaping the future of healthspan, muscle growth, and longevity. MiniCircle has developed cutting-edge plasmid-based gene therapy targeting Follistatin and Klotho, two powerful longevity genes.
Dr. Rossner breaks down what gene therapy is, how it works at the cellular level, and how MiniCircle’s non-viral, reversible gene therapy is making this technology more accessible, affordable, and safe. From muscle preservation to cognitive enhancement, this episode explores the scientific breakthroughs, real-world results, and future potential of genetic interventions for longevity.
Key Topics Discussed:
Understanding Gene Therapy & How It Works
Gene therapy modifies or enhances DNA to optimize health and longevity.
DNA is the core code of life, instructing every cell on how to function.
MiniCircle’s gene therapy uses plasmid technology—a non-viral, non-integrating method that modifies a small number of belly fat cells to produce beneficial proteins.
Unlike CRISPR or viral-based gene therapy, MiniCircle’s approach is reversible and does not permanently alter DNA.
Follistatin & Its Role in Longevity
Follistatin inhibits Myostatin & Activin, two proteins that limit muscle growth and regeneration.
Increased muscle mass and fat-free mass can enhance longevity, reduce inflammation, and prevent frailty as we age.
MiniCircle’s studies show positive effects on body composition, muscle retention, and even bone density.
Participants in clinical trials saw improvements in strength, endurance, and recovery within a few weeks to months.
Klotho: The Brain & Longevity Gene
Klotho is a longevity-associated protein linked to cognitive function, kidney health, and extended lifespan.
Higher Klotho levels enhance brain function, protect against neurodegeneration, and support cellular repair.
Klotho was first identified in mouse studies, where overexpression led to a significant increase in lifespan.
MiniCircle is currently developing a Klotho gene therapy, expected to be available in the near future.
Clinical Trials & Real-World Results
MiniCircle conducted human clinical trials showing significant reductions in epigenetic age (measured by True Diagnostic).
Participants saw an average epigenetic age reduction of 7 years.
An 80-year-old participant experienced improved mobility, bone density, and increased energy.
Both men and women across various age groups saw noticeable benefits in body composition and overall well-being.
The Process of Receiving Gene Therapy
MiniCircle operates outside the U.S. due to FDA regulations.
Patients must travel to approved clinics in Honduras (GARM Clinic) or Eterna Health to receive treatment.
The procedure involves a simple subcutaneous injection into belly fat, where the modified cells act as factories producing therapeutic proteins.
The effects typically last around a year, and the therapy can be repeated or adjusted as needed.
Reversibility & Safety of MiniCircle’s Gene Therapy
MiniCircle uses a unique kill-switch mechanism to reverse the gene therapy if needed.
Plasmid-based therapy is safer than viral-based therapy because it does not permanently alter the genome.
So far, no major adverse effects have been reported in trials.
The Future of Gene Therapy & Accessibility
Current cost: ~$25,000 per treatment, but MiniCircle aims to lower costs over time.
Future advancements could lead to at-home gene therapy injections similar to peptide therapy.
Dr. Rossner discusses the ethical debates around genetic enhancement and whether society should embrace longevity-focused genetic interventions.
MiniCircle is actively working to bring new genetic therapies to market, including treatments for APOE4 (Alzheimer’s risk), MTHFR variants, and immune optimization.
Where to Find Dr. Ryan Rossner & MiniCircle
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Disclaimer:
This episode is for informational purposes only and not a substitute for medical advice. Please consult a healthcare professional before starting any new treatments or protocols.
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