Ron Lane: Chairman & CEO of HOPE-Neuron therapeutx

Episode 86: Reversing Neurodegeneration? Inside the Breakthrough Cell-Signaling Therapy Targeting ALS, Alzheimer’s & Parkinson's.

🧬 Episode Overview

In this powerful and deeply personal episode, Jenny Jones (BiohackerBlondie) sits down with Ron Lane, Executive Chairman & CEO of Hope Neuron Therapeutics, to explore a revolutionary new approach to neurodegenerative and autoimmune disease—one that uses the body's own cellular intelligence to restore healing.

Ron shares the incredible scientific journey that led him from academic neuroscience to creating a therapy that shifts the immune system from self-destruction to self-repair, with promising results in ALS, Alzheimer’s, and autoimmune-driven conditions.

This episode blends high-level science with emotional storytelling. Ron opens up about his late wife’s battle with Alzheimer’s, how that experience fueled his mission, and why he believes Hope Neuron’s technology may reshape the future of neurodegenerative medicine.

If you or someone you love has been impacted by ALS, Alzheimer’s, MS, autoimmune issues—or if you're fascinated by longevity science—you need this episode.

🔬 1. From Neuroscience Researcher to Founder: The Origin of Hope Neuron

Ron’s path began decades ago during his PhD and postdoctoral work under pioneers in neuroanatomy and physiology. But when his wife was diagnosed with a malignant tumor—eventually progressing into Alzheimer’s—everything changed.

Ron left academia to care for his wife and, during those years, began researching neurodegeneration relentlessly. He realized:

• Most neurodegenerative diseases share autoimmune mechanisms

• The body inherently knows how to heal, but disease collapses these pathways

• The key was not developing new drugs—but restoring the body’s existing healing signals

  
  

His wife’s passing became the catalyst for a mission: develop a therapy that restores immune balance and cellular health using the patient’s own biology.

This is how Hope Neuron Therapeutics was born.

⚗️ 2. The Core Discovery: Switching the Immune System from “Killing” to “Healing”

At the heart of Ron’s work is one concept:

Your immune system has two modes:

• M1 – The “killer” immune state (inflammation, destruction, autoimmunity)

• M2 – The “healing” immune state (repair, regeneration, anti-inflammation)

  
  

In diseases like ALS, Alzheimer’s, MS, Parkinson’s, and autoimmune disorders, the body becomes locked in the M1 state—essentially attacking itself.

Hope Neuron’s therapy:

• Takes a small amount of a patient’s own blood

• Processes it mechanically (no drugs, no chemicals)

• Stimulates it with controlled oxygenation to signal M2 activation

• Reinfuses it into the patient to shift their immune system back to healing mode

  
  

This is not pharmaceutical.It is not gene therapy.It is cell whispering—amplifying the body’s own repair signals.

📌 Key Insight:

“We don’t heal the patient. The patient heals themself. We simply remind the body how.”

🧪 3. The ALS Breakthrough: What Animal Studies Revealed

Hope Neuron’s first target is ALS, a rapidly fatal neurodegenerative disease with almost no effective treatments.

Using mice engineered with human ALS genes (the standard model), Ron’s team observed:

• Untreated ALS mice fell off the treadmill repeatedly and died quickly (20–40 months in humans)

• Treated mice ran normally—showing drastically restored motor function

• The effect persisted as long as treatments were repeated

  
  

This repeated success convinced Ron and independent researchers that the mechanism was real and powerful.

Treatment Frequency (Estimated)

Based on animal models and FDA-validated calculations:

➡️ Once every 3–4 months to maintain healing immune signaling.

🧬 4. Moving Into Human Trials: What Comes Next

Hope Neuron is preparing to begin human trials at:

Barrow Neurological Institute – the #3 ALS clinic in the world

The goal: Prove safety, then rapidly pursue humanitarian device approval through the FDA—a fast-track pathway for rare diseases.

Ron anticipates:

• Safety studies completed by end of next year

• Potential FDA approval soon after

• ALS patients receiving therapy within ~12–18 months

  
  

This is extraordinarily fast compared to traditional drug development.

🧠 5. Could This Work for Alzheimer’s, Parkinson’s, MS, and Autoimmune Disease?

According to Ron: Yes—because the root mechanisms overlap.

Most neurodegenerative and autoimmune conditions share:

• Chronic inflammation

• M1 dominance

• Cytokine imbalance

• Impaired apoptotic pathways

• Immune cells attacking self tissue

  
  

By restoring M2 healing signals, the therapy may help:

• Clear inflammatory cytokines

• Reduce autoimmune misfiring

• Improve neuronal survival

• Support tissue regeneration

• Improve functional biomarkers over time

  
  

Hope Neuron plans to move directly into Alzheimer’s and cancer following ALS.

🧬 6. Biomarkers Ron Recommends Testing

Ron lists key cytokines indicating autoimmune activation and neuroinflammation:

M1 (inflammatory / disease-driving)

• IL-1β

• IL-12

• IL-18

• IL-6

• IL-23 / IL-24

M2 (healing / anti-inflammatory)

• IL-4

• IL-5

• IL-10

These biomarkers can give early insight into neurodegeneration, autoimmune activation, and inflammatory disease.

🌱 7. Ron’s Longevity Philosophy: What He Personally Does Daily

Ron emphasizes simplicity:

1. Exercise (4–5x/week)

The strongest longevity lever he knows.He cites studies showing exercise outperformed pharmaceutical interventions—even in COVID outcomes.

2. Diet

His #1 toxin to avoid?Processed, inflammatory foods.

He prioritizes:

• Short- and medium-chain fatty acids

• Low animal protein

• Gut-supportive foods

• Foods that minimize autoimmune triggers

  
  

3. Supplements

He takes:

• Tocotrienols

• Targeted anti-inflammatory nutrients

• Select pharmaceuticals where evidence supports usage

  
  

4. Stress Reduction

Ron explains chronic stress literally rewires the brain and accelerates aging.

His advice:

“Relax. Make choices that promote hope, not fear.”

✨ Key Takeaways

✔ Neurodegeneration and autoimmunity share the same core mechanism: immune imbalance

✔ Hope Neuron’s therapy restores the body’s natural healing signals (M2)

✔ ALS mouse models showed remarkable recovery using patients’ own blood

✔ Human trials are expected soon through Barrow Neurological Institute

✔ Biomarkers like IL-1β, IL-12, IL-18, IL-6, IL-10 provide early disease insight

✔ Diet, exercise, and stress regulation remain foundational longevity tools

✔ This therapy may extend beyond ALS into Alzheimer’s, Parkinson’s, MS, and cancer

📍 Learn More About Hope Neuron Therapeutics

🌐 Website: HopeNeuron.com

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• Disclaimer:

  
  

  This episode is for informational purposes only and not a substitute for medical advice. Please consult a healthcare professional before starting any new treatments or protocols.