Episode 47: What is NAD? Why It’s Key to Longevity and Energy, and How to Test Your Levels with Dr. Jin-Xiong She
Episode Highlights
Jenny Jones interviews Dr. Jin-Xiong She, a pioneering molecular biologist specializing in aging and longevity, and the Director of Longevity Research at Minicircle. The conversation dives deep into the science behind NAD, its importance for energy and health, and how to test and optimize NAD levels for a longer and healthier life.
Key Takeaways
What is NAD?
NAD (Nicotinamide Adenine Dinucleotide) is a coenzyme essential for over 500 cellular processes, including energy production (ATP).
It serves as the "life force" for cells, enabling enzymes to function and promoting overall health and longevity.
NAD levels decline significantly with age and are often deficient in individuals with poor health or chronic conditions.
Why is NAD Important?
Energy Production: NAD is critical for ATP production, which fuels cellular activity.
Cognitive Function: Optimized NAD levels improve brain health and reduce brain fog.
Circadian Rhythm: Supports gene expression involved in sleep cycles.
Inflammation Reduction: Helps lower chronic inflammation, benefiting conditions like arthritis and allergies.
Longevity: NAD optimization is foundational to extending healthspan and lifespan.
NAD Deficiency
NAD levels decrease with age and poor health.
Even teenagers and young adults can show signs of NAD deficiency.
Causes include:
Inflammation (especially due to the enzyme CD38, which depletes NAD).
High-intensity exercise, which increases ATP demand.
Environmental toxins like heavy metals and plastics.
Testing NAD Levels
Dr. Jin has developed an innovative, stable test for NAD levels.
Process:
Use a finger-prick blood sample on a test card.
Mail it to the lab for analysis.
Receive results within a week, indicating whether your NAD levels are deficient.
Retesting after supplementation or lifestyle changes ensures optimization.
How to Optimize NAD Levels
Supplements:
NAD precursors like NMN (Nicotinamide Mononucleotide) and NR (Nicotinamide Riboside).
Dr. She’s product, Vitality Boost, combines NMN with creatine, ribose, and other synergistic compounds for superior efficacy.
Avoid over-supplementation; excess NAD can lead to harmful effects like increased vascular inflammation.
Lifestyle Factors:
Regular exercise (but avoid overtraining without replenishing NAD).
Saunas and infrared therapies.
Avoid toxins and reduce inflammation.
Dietary Interventions:
Creatine: Improves energy storage and is especially beneficial for brain health.
Turmeric: Reduces inflammation.
Fisetin or Quercetin: Acts as a senolytic and antioxidant.
Dr. She’s Recommendations
Key Supplements:
NMN or NR: Proven precursors for NAD production.
Creatine: Enhances energy storage and supports brain and muscle health.
Turmeric: Anti-inflammatory.
Fisetin: For senolytic and antioxidant benefits.
Vitamin D, K2, and E: Essential micronutrients.
Testing Recommendations:
Regularly test NAD levels for accurate optimization.
Use Dr. She’s test kits to personalize supplementation protocols.
Avoid High-Dose Niacin: Can cause excessive NAD and harmful metabolites, increasing inflammation.
References and Resources
Dr. Jin-Xiong She’s Product: Vitality Boost
Combines NMN, ribose, creatine, and nicotinamide for maximum NAD optimization.
Website for Testing and Products: Jinfiniti.com
Where to Find Dr. Jin-Xiong She
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Disclaimer:
This episode is for informational purposes only and not a substitute for medical advice. Please consult a healthcare professional before starting any new treatments or protocols.
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