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Mona Rosene, MS, RD, PHD: Global Director, Scientific & Medical Affairs at Niagen

Updated: Aug 28, 2025

Episode 75: Low energy, brain fog, faster aging? NAD decline may be the reason. Today, Mona from Tru Niagen joins me to unpack how NAD, NR, and Tru Niagen are changing the future of energy, repair, and longevity.



🎙️ Episode Summary


Low energy. Brain fog. Slow recovery. Early signs of aging. These are struggles many of us accept as “normal”—but at the cellular level, they’re often tied to one thing: declining NAD+.


NAD (nicotinamide adenine dinucleotide) is one of the body’s most essential molecules. It powers our mitochondria to produce energy, helps repair DNA, and supports resilience against stress and toxins. But here’s the catch—NAD levels drop dramatically with age, stress, poor diet, and even lack of sleep. By midlife, you could be running on nearly half the NAD you had in your 20s.


In this episode of the BiohackerBlondie Podcast, Jenny sits down with Mona Rosene, Global Director of Scientific Affairs at Niagen Bioscience, the company behind Tru Niagen. Mona has spent her career researching cellular health, and in this conversation she breaks down the latest science on NAD, nicotinamide riboside (NR), and how Tru Niagen is pushing the boundaries of supplementation, IV therapies, and testing that make NAD support measurable, trackable, and truly effective.


This is more than just another supplement discussion—it’s a deep dive into the future of cellular optimization and what it means for energy, longevity, performance, and healthy aging.


🔬 What You’ll Learn


🧬 The Role of NAD+ in Health and Longevity

  • Why NAD is essential for energy metabolism, mitochondrial function, and cellular repair.

  • How NAD levels naturally decline over time—and why that accelerates aging.

  • The surprising connections between NAD and brain function, immunity, metabolism, and even skin health.


💊 The Science of Nicotinamide Riboside (NR)

  • Why NR is the most clinically studied and validated NAD precursor.

  • How it compares to other forms like NMN, and why Tru Niagen chose this patented pathway.

  • The clinical trials showing real increases in NAD levels in humans.


💉 IV Therapy: NAD vs. Niagen IVs

  • The rise of NAD IV clinics and why traditional NAD drips are slow and sometimes painful.

  • New research showing how Niagen IVs can be safer, faster, and more effective.

  • Who benefits most from IVs versus oral supplementation.


📊 Testing and Tracking Your NAD Levels

  • How Tru Niagen developed the first dry blood spot test for NAD.

  • Why testing matters for separating hype from reality.

  • How to use these tests to track your progress over time.


✨ NAD Beyond Longevity

  • How NAD impacts skin aging and resilience against sun damage.

  • Why athletes are turning to NAD for improved performance, recovery, and resilience.

  • The role of NAD in supporting immune function and reducing inflammation.


🌍 The Bigger Picture

Mona also shares how Tru Niagen is raising the bar for supplement quality with third-party certifications that go far beyond what most brands attempt:

  • NSF Certified for Sport – ensuring purity and no banned substances.

  • Alkemist Assured – verifying ingredient authenticity and potency.

  • cGMP Manufacturing – pharmaceutical-grade quality controls.

  • ISO 17025 Laboratory Testing – global gold standard for accuracy and reliability.

  • Kosher & Halal certifications – ensuring inclusivity and strict quality adherence.


This multi-layered validation process eliminates the typical “just trust us” problem in the supplement industry—replacing it with science-backed assurance you can actually verify.


💡 Key Takeaways

  • NAD is at the core of energy, repair, and resilience—but it declines with age and stress.

  • NR is the most validated and safest way to restore NAD levels consistently.

  • Testing matters—because you can’t optimize what you don’t measure.

  • Supporting NAD impacts everything from longevity to beauty to athletic performance.

  • Tru Niagen stands apart because of its unmatched third-party certifications.


🔗 Products & Tools Mentioned

Available on Spotify, Apple Podcasts, Amazon Music, and all major platforms.


🎁 Special Offer for Listeners

Use code Jenny20 at TruNiagen.com for a discount on your order.


🔥 Why You Should Listen

If you’ve ever struggled with low energy, brain fog, slow recovery, or premature aging—this episode connects the dots between your symptoms and what’s happening at the cellular level. With Mona’s expertise, you’ll walk away understanding exactly how NAD works, why Tru Niagen is different, and how to start supporting your body’s most fundamental molecule.


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